Journal of Statistical Physics 148
, 636 (2012)
Protein Sequence and Structure: Is One More Fundamental than the Other?
Jayanth R. Banavar, T. X. Hoang, F. Seno, A. Trovato, A. Maritan
We argue that protein native state structures reside in a novel “phase” of matter
which confers on proteins their many amazing characteristics. This phase arises from the
common features of all globular proteins and is characterized by a sequence-independent
free energy landscape with relatively few low energy minima with funnel-like character.
The choice of a sequence that fits well into one of these predetermined structures facilitates
rapid and cooperative folding. Our model calculations show that this novel phase facilitates
the formation of an efficient route for sequence design starting from random peptides.